Open access
Aug 2026
Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence
DAXX, a histone chaperone and RTE repressor, is downregulated during aging, preserves microglia homeostasis and inhibits cellular senescence, highlighting the importance of heterochromatin maintenance in preserving adult microglial identity and plasticity, with broader implications for brain homeostasis, healthy aging...
Xin Yan, Christina Georgopoulou, Hang-Mao Lee et al.
· Nature Neuroscience · 1 citation