Open access
Oct 2026
Sparsely Phosphorylable Residues, Tuned by Agonist Chemotype, Shapes GPCR Signaling
It is shown that the melanocortin-4 receptor (MC4R), a central regulator of energy homeostasis, achieves remarkably diverse and pathway-selective signaling through a sparse set of strategically positioned regulatory phosphoresidues, arguing that GPCR signaling diversity does not necessarily require an extensive phospho...
M. Borah, Sarfraz Ahmed, Mahek Agrawal et al.
· bioRxiv · 0 citations