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Author

Moataz A. Shaldam

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4 papers indexed here

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Open access Sep 2026

Tailored [1,2,4]triazolo[1,5-a]pyrimidine hybrids as promising anti-inflammatory agents with COX/5-LOX/ROS/IL-6 multifunctional inhibitory activity: design, synthesis, SAR, and in silico study

To develop potent anti-inflammatory agents with safer profiles, a hybridization approach combining [1,2,4]triazolo[1,5-a]pyrimidine/chalcone (5a–g) and [1,2,4]triazolo[1,5-a]pyrimidine/pyrazole (6a–g) has been rationally designed to synthesize potential COX/5-LOX/ROS/IL-6 multifunctional inhibitors. All synthesized hyb...

Esraa Elazony, Nermine A. Osman, Moataz A. Shaldam et al. · 0 citations
Open access Sep 2026

Design and synthesis of 1,3,4-oxadiazole-tethered N-substituted isatin hybrids as SARS-CoV-2 main protease inhibitors: biological evaluation, kinetic investigation, and in silico studies

The ongoing emergence of SARS-CoV-2 mutations underscores the urgent need for new antivirals that target key viral proteins. This study describes the design, synthesis, and evaluation of two series of 1,3,4-oxadiazole-tethered N-substituted isatin hybrids as inhibitors of the SARS-CoV-2 main protease (Mpro): 1,2,3-tria...

T. Al-Warhi, Md Sofequl Islam Mukim, Zainab M. Elsayed et al. · 1 citation
Review Sep 2026

Mutant isocitrate dehydrogenase in cancer: Structural biology, small-molecule inhibitors, and future drug discovery strategies.

This review classifies mutant IDH inhibitors by chemical scaffold and relates their binding in the allosteric pocket to structure-activity trends, isoform selectivity, brain penetration, and clinical outcome.

Moataz A. Shaldam, Anwar A. El-Hamaky, Nourhan A. Khattab et al. · 0 citations

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