Author

Mohamed S. Donia

2 papers indexed here

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Open access Sep 2026

Biosynthetic origin of anticancer dolastatin 15 reveals a noncanonical NRPS architecture enabling 2-keto acid activation.

Elucidating the biological origins and biosynthetic pathways of marine natural products remains a major challenge, particularly for compounds derived from microbial consortia. Here, we identify the marine cyanobacterial genus Dapis as the source of the potent anticancer natural product dolastatin 15 using genome-resolv...

Man-Yun Chen, Jie Liu, Hsin-Ying Tsai et al. · Proceedings of the National... · 0 citations

Open access Jul 2026

Digestion-resistant proteins support the healthy metabolite profiles associated with plant-based diets.

It is shown that fiber and digestion-resistant protein work in concert to shift the phenol profile by altering gut microbiome nutrient supply, and digestion-resistant plant protein modulates microbiome metabolism and, together with fiber, supports healthy metabolite profiles associated with plant-based diets.

Jenna E. AbuSalim, Michael R. MacArthur, Meera Gupta et al. · Proceedings of the National... · 1 citation