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Author

Mohamed Shanshal

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Open access Oct 2026

Early-Phase Drug Development in Rare Cancers: A Decade of Progress and Future Directions

Rare cancers represent a substantial health burden, comprising 25% of cancer mortality. Early-phase oncology trials are essential for rare cancers, where limited patient numbers, biological heterogeneity, and the absence of established standards of care necessitate innovative approaches to drug development. Advances in...

Y. Myat, K. Thein, Lujain Mahmood et al. · 0 citations
Review Open access Aug 2026

T-Cell Engagers in Lung Cancer: A Comprehensive Literature Review from Tarlatamab Approval to Next-Generation Strategies

Rational TCE design, incorporating costimulatory signaling, antigen selection informed by parallel ADC validation data, and evidence-based combination strategies, offers the most credible path toward expanding this platform’s impact in metastatic lung cancer.

Adnan Saydawi, Sameh Madanieh, Stephanie L. Echeverria et al. · 0 citations

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