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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Mohamed Trebak

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2 papers indexed here

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Open access Sep 2026

ORAI Ca2+ Channels and STIM1 Drive Capillary-to-Arteriole Communication in Neurovascular Coupling

Neurovascular coupling (NVC), initiated by the brain’s dense capillary network, matches blood flow to neuronal activity, yet key underlying mechanisms remain unresolved. We found that ORAI1 channels and their regulator STIM1, the main drivers of store-operated Ca2+ entry, are essential for communicating neuronal metabo...

Boris Lavanderos, Alfredo Sanchez-Solano, Wan-Chun Zhu et al. · 1 citation
Open access Sep 2026

TRPML1 loss disrupts lysosome-mitochondria homeostasis and sensitizes MDA-MB-231 triple-negative breast cancer cells to chemotherapy.

Signaling mechanisms at the lysosome-mitochondria interface form a critical network that enables cancer cells to maintain mitochondrial quality control, adapt to metabolic stress, and survive therapy. However, the incomplete understanding of the mechanisms coordinating this network has limited the development of effect...

A. K. Syeda, Shekoufeh Almasi, Cory J. Benson et al. · 0 citations

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