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Author

Mohammad Jawaıd Akhtar

3 papers indexed here

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Aug 2026

Design, Synthesis, and Molecular Docking Studies of Coumarin-chalcone Conjugates as Selective TNF-α and Weak COX-2 Inhibitors with Efficacy as an Antioxidant.

INTRODUCTION Inflammation and oxidative stress play important roles in the development of various chronic diseases, necessitating compounds with dual therapeutic potential. METHODS A series of (E)-7-hydroxy-4-methyl-6-(3-(substituted phenyl)acryloyl)-2H-chromen-2-one (7a-m) were synthesized starting from 7-hydroxy-4-...

Dalaa Ali El-Jadayel, Husna Khalifa Al-Busaidi, Zainab Hamood Al-Balushi et al. · 0 citations
Review Aug 2026

Unlocking the pharmacological potential of rhodanine derivatives: Drug design strategies and structure-activity relationships

Rational design strategies for rhodanine-based heterocycles and their therapeutic potential as antibacterial, anti-diabetes, anti-Alzheimer’s, anticancer, anthelmintic, anti-obesity, and against COVID-19 are discussed.

R. Nath, Lakshminarayan Das, Arka Chakraborty et al. · 0 citations
Review Open access Sep 2026

Rational drug design, synthetic and artificial intelligence approaches for bioactive heterocycles: advances and perspectives.

Heterocyclic scaffolds are vital to medicinal chemistry due to their versatility, diversity, and ability to target various biological molecules. This review covers advances in designing and synthesizing bioactive heterocycles, highlighting structure-based drug design (SBDD) and ligand-based drug design (LBDD) approache...

Debajit Dewan, Bhupender Nehra, R. Nath et al. · 0 citations

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