Tyrosine phosphorylation of the scaffold protein IQGAP1 by VEGFR2 modulates cell proliferation.
IQGAP1 (IQ motif-containing GTPase activating protein 1), a scaffold protein with >250 interacting partners, regulates several intracellular signaling cascades, thereby modulating cell functions. Post-translational modifications of IQGAP1 by ubiquitination or phosphorylation have been shown to alter its interactions wi...