Cardioprotective role of vincamine in cyclophosphamide-induced cardiotoxicity through modulation of AMPK/SIRT1, PI3K/Akt, and MAPK pathways.
VIN attenuated changes in the AMPK/SIRT1 and PI3K/Akt axes, MAPK, TLR4/NF-κB p65 signaling, as well as NLRP3-related signaling in a dose-responsive manner, and its cardioprotective effects were accompanied by improved redox balance, increased AMPK/SIRT1 and PI3K/Akt expression, reduced phosphorylated MAPK abundance, an...