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Overall, CNPs are a transformative nanoplatform with great potential to improve the delivery of biopharmaceuticals via the oral route, enhancing patient adherence and therapeutic efficacy.
The engineering design, fabrication methods and biomedical uses of nanofibers for cancer therapeutics, as well as for extracellular matrix (ECM)-mimicking tumor models are detailed.
PEGylation has been shown to extend the circulatory lifetime, enhance drug deposition in tumors, and minimize off-target toxicity, and more effective design solutions should be employed, including stimuli-responsive liposomes and patient-tailored methods.
The results show that AI and robotics improve assay reproducibility, optimize chemical reactions, and enable the conversion of a hit into a lead in the initial stages of drug development.
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