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Molly Endicott

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Open access Aug 2026

DNA methylation signatures of sporadic colorectal cancer with microsatellite instability

ABSTRACT Colorectal cancer (CRC) is a heterogeneous disease shaped by genetic and epigenetic alterations. Approximately 20% of CRCs exhibit widespread CpG island hypermethylation, termed the CpG Island Methylator Phenotype (CIMP), frequently accompanied by MLH1 promoter hypermethylation, deficient mismatch repair (dMMR...

Rebecca Ward, Molly Endicott, B. Mallabar-Rimmer et al. · 0 citations

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