Moncef Zouali

mRNA therapeutics for restoring immune tolerance in autoimmune diseases.

Autoimmune diseases arise from breakdown of immune tolerance and are commonly treated with broad immunosuppression that limits efficacy and increases toxicity. For drug discovery, mRNA therapeutics offer a programmable, modular platform to develop antigen-specific and mechanism-driven autoimmune therapies. mRNA-based a...

A two-step model of age-associated autoreactivity: B cell-intrinsic aging meets inflammaging.

B Lymphocytes in Latent Autoimmune Diabetes in Adults: From Autoimmune Activation to Immunometabolic Heterogeneity and Precision Therapeutic Perspectives

Findings support a model in which B lymphocytes act as both effector and regulatory components within a dynamic immunometabolic network that determines disease heterogeneity and progression, and highlight B lymphocyte‐targeted interventions as potential, although still investigational, therapeutic strategies aimed at p...