Review
Open access
Oct 2026
IL-1 signaling in cancer-associated fibroblasts: shaping fibroblast heterogeneity, tumor immunity, and therapeutic resistance.
IL-1 signaling is a central regulator of inflammation and immune responses within the tumor microenvironment, with IL-1α and IL-1β acting as key mediators. Tumors exploit IL-1 signaling through complex autocrine and paracrine interactions among malignant cells, immune cells, and cancer-associated fibroblasts (CAFs) to...
Monica Gabola, M. Benzarti, Elisabeth Letellier
· Seminars in Immunology · 0 citations