Author

Monzy Thomas

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Open access Jul 2026

TFAP2A links drug resistance to antitumor immunity

This work found that BRAF/MEK inhibitors significantly upregulate TFAP2A, and identifies TFAP2A as a shared driver of both targeted therapy resistance and immunosuppression, offering a one-stone-two-bird strategy to overcome drug resistance and elicit antitumor immunity.

Haiwei Mou, Veronika Yakovishina, Kristen M DeRosa et al. · bioRxiv · 0 citations