Moritz Wagner

Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont.

Peloruside A, a polyketide macrolide identified in the marine sponge Mycale hentscheli, is a promising anticancer drug candidate due to its ability to stabilize tubulin at a nontaxoid binding site. Substantial efforts were made to improve the supply of this scarce substance through chemical synthesis and mariculture, h...