Open access
Aug 2026
Multiscale mechanistic modeling for the rational design of novel dual-target candidates against acetylcholinesterase and NADPH oxidase: an advanced computational study
Introduction Alzheimer’s disease is a complex neurodegenerative illness strongly associated with oxidative stress, which requires immediate intervention for therapeutic agents with potent antioxidant properties. Methods In this work, novel derivatives based on benzofuran and pyrazole scaffolds were designed and assesse...
Mohamed El Fadili, M. Er-rajy, S. Mujwar et al.
· Frontiers in Chemistry · 0 citations