Moustafa A. Tageldein

Strategy-based design for the identification of next generation β-lactam antibiotics that evade resistance from Gram-negative pathogens.

INTRODUCTION β-Lactam antibiotics have defined antibacterial chemotherapy for over eight decades and remain indispensable for the treatment of bacterial infections. Despite their clinical success, escalating antimicrobial resistance, particularly among Gram-negative pathogens, continues to impair their efficacy. This c...