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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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M.S. Sigfúsdóttir

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Open access Jul 2026

Model-guided discovery of MTOR-oriented synergistic drug combinations in colorectal cancer

Colorectal cancer (CRC) exhibits high genetic heterogeneity and frequent resistance to single-agent therapies, highlighting the need for rationally designed drug combinations. We apply a mechanistic modelling framework to prioritise synergistic combinations in 16 CRC cell lines. Simulations of 210 double perturbation...

Viviam Solangeli Bermúdez Paiva, H. Bwanika, M.S. Sigfúsdóttir et al. · 0 citations

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