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Author

Mu-Shui Dai

2 papers indexed here

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Sep 2026

Abstract B126: Targeting USP36 as a therapeutic strategy for high-MYC expressing pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by poor therapeutic response and aggressive disease progression driven heavily by the c-MYC oncoprotein. Ubiquitin-specific protease 36 (USP36) is a nucleolar deubiquitinating enzyme that enhances the stability of criti...

Assmaa ElSheikh, Ping-Chuan Zhang, Xiao-Yan Wang et al. · 0 citations
Open access Sep 2026

IFNγ-dependent tumor-cell MHC-II is restrained by MAPK signaling and associated with immunotherapy responsiveness in pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment (TME) and poor prognosis. Although major histocompatibility complex class II (MHC-II) is typically expressed by professional antigen-presenting cells, its regulation and significance in malignant PDAC cells remain un...

Can-Ping Chen, Yi Zhang, Xi Li et al. · 0 citations

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