Mu-Yang Li

Structure-Guided Stepwise Engineering of a Microbial Glycosyltransferase for Highly Regioselective and Efficient Biosynthesis of Salidroside

Uridine diphosphate glycosyltransferases (UGTs) are among the key rate-limiting enzymes in the biosynthesis of salidroside. Plant-derived UGTs often exhibit poor solubility and low catalytic activity, whereas microbial UGTs typically show insufficient regioselectivity for salidroside production. In this study, we per...