Muhammad Rafiq

Bioactive fucoidan-coated polylactic acid-based nanoparticles for co-delivery of vincristine and thymoquinone: Enhanced antitumor efficacy with reduced vincristine-associated toxicity.

The clinical efficacy of vincristine (VIN) is often restricted by dose-limiting toxicity, poor tumor selectivity, and rapid systemic distribution. Another biomolecule, thymoquinone (TQ), has negligible toxicity, but poor aqueous solubility and limited bioavailability hamper its use in cancer therapy. In this study, a f...