Author

Muhammad Suleman

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Open access Sep 2026

Genetic basis of Charcot-Marie-Tooth disease in Pakistani consanguineous families

Charcot-Marie-Tooth (CMT) is a group of inherited neuromuscular disorders with diverse clinical features such as muscle weakness and atrophy of the distal regions, foot deformities, sensory loss and decreased or absent reflexes. With the diverse inheritance patterns including dominant, recessive, and X-linked, it exhib...

Zafar Ali, M. Jameel, J. Klar et al. · Frontiers in Neurology · 0 citations

Open access Sep 2026

Mechanistic inhibition of herpes simplex virus-1 UL21 immune-evasion function by natural-product scaffolds: A multi-tier docking, dynamics, and energetic profiling approach

Alpha-herpesviruses, particularly herpes simplex virus type 1 (HSV-1), establish lifelong latency and employ multiple strategies to evade host immunity, thereby sustaining infection. A key mediator of this immune evasion is the viral tegument protein, unique long 21 (UL21), which disrupts the host cyclic GMP-AMP syntha...

Muhammad Suleman, Imtiaz Ali, A. M. Sayaf et al. · PLoS ONE · 0 citations