Open access
Aug 2026
Cationic metal-binding coumarin amphiphiles as membrane-active antimicrobial agents.
The results suggest that incorporating metal-binding headgroups into amphiphilic scaffolds may engage a distinct mode of action compared to traditional small-molecule AMP mimetics, resulting in increased antimicrobial potency and selectivity over mammalian membranes.
Samuel O. Nitschke, Anteneh Amsalu, Muhammed Awad et al.
· European journal of medicina... · 0 citations