Frailty is characterized by decreased physiological reserves and impaired functioning of multiple systems. This study investigated the association between frailty and hospital outcomes such as postoperative complications, length of hospital stays, readmission rates, and functional outcomes following THA.
Data for this study were retrieved from the Nationwide Inpatient Sample (NIS) database, 2018–2021. Adult patients 18 years and above with a primary diagnosis of THA were identified using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-10-CM) codes. We identified frail patients using the Hospital Frailty Risk Score (HFRS). The main outcomes of this study were surgical complications, medical complications, in-hospital mortality, and prolonged length of stay.
There were 1,725,550 THA hospitalizations, of which 9.1% (156,275) were frail. Logistic regression analysis showed that frailty was associated with significantly greater odds of surgical complications (OR, 4.77, 95% CI: 4.27–5.33), medical complications (OR, 2.68, 95% CI: 2.59–2.76), other complications (OR, 8.13, 95% CI: 7.53–8.78), any complications (OR, 3.17, 95% CI: 3.08–3.27), mortality (OR, 2.74, 95% CI: 1.99–3.54), and prolonged length of stay (OR, 5.25, 95% CI: 5.05–5.45).
Frailty significantly impacts postoperative outcomes in patients undergoing THA, leading to increased complications, in-hospital mortality, and prolonged hospital stays. A proactive approach for managing frailty could lead to better resource utilization and enhanced recovery following THA.
Sandeep Appunni, Mukesh Roy, Krishna Raj Kunnath Rajappan et al.· Current Orthopaedic Practice· 0 citations
Abstract Background Surgical resection is a standard treatment for large and/or symptomatic newly diagnosed brain metastases (BM). GammaTile brachytherapy delivers immediate intracavitary radiation at surgery and may reduce delay in postoperative treatment. Despite increased usage and adoption, prospective data remain limited. Methods We analyzed an ongoing multicenter, prospective Phase IV registry (NCT0442738) of patients undergoing BM resection followed by GammaTile brachytherapy. Primary outcome was overall survival (OS); secondary outcomes were local control (LC) and distant brain failure (DBF). Time-to-event endpoints were estimated by Kaplan-Meier methods, and Cox models were used to identify predictors of outcome. Results 89 patients with 95 lesions were treated with resection and brachytherapy. Median age was 64 years (range: 28–81), 56.2% were male, and median KPS score was 80 (range: 30-100). Primary histology included predominantly lung (36%), followed by melanoma (12.4%) and breast (11.2%). The median BM diameter was 3.2cm (range 1.1-5.5cm) and most lesions were supratentorial (84.2%). Gross total resection was achieved in 86.3% of patients. At analysis, 48.8% of patients had died. Median OS was 8.6 months (95% CI: 6.0-20.1 months), with 6- and 12-month OS rates of 59.4% and 45.1%, respectively. Local failure occurred in 7.9% patients. The 6- and 12-month LC rates were 96.9% and 92.5%, respectively. DBF occurred in 19% of patients, with 6- and 12-month DBF-free rates of 82.2% and 68.4%. Melanoma histology was associated with worse DBF on multivariable analysis (HR: 5.31, p=0.043). Seizures occurred in 6.7% of patients, while intracerebral hemorrhage and cerebral edema were observed in 1.1% and 2.2% patients, respectively. Conclusions In this prospective registry, resection followed by GammaTile brachytherapy achieved excellent local control, and manageable toxicity in newly diagnosed BM. These findings support that GammaTile brachytherapy is a promising strategy for large or symptomatic BM. Future work to better define patient selection is planned.
Ruchit P. Jain, Z. Sarfraz, Mukesh Roy et al.· Neuro-Oncology Advances· 0 citations
