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Author

Murat Kasap

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Oct 2026

Early preventive effects of a Cathepsin S inhibitor on inflammation in a rat model of endotoxin-induced uveitis.

OBJECTIVES Uveitis, an inflammation of the uveal tissue, can cause permanent vision loss. A previous study revealed elevated levels of cathepsin S in the tear proteomic analyses of patients with juvenile idiopathic arthritis-associated uveitis. This study investigates the effects of a cathepsin S inhibitor on inflammat...

Büşra Yılmaz Tuğan, S. S. Gocmez, G. Duruksu et al. · 0 citations
Open access Aug 2026

Biphasic Temporal Remodeling Of The Proteome In A Polyglutamine-Expanded Huntingtin In Vitro Aggregation Cell Model: From Early Rna-Regulatory Compensation To Selective Mitochondrial Energy Failure

Findings define a biphasic course of huntingtin toxicity and highlight an early therapeutic window in which intervention is most likely to be applied, prior to irreversible deterioration of mitochondrial respiratory function.

Ekin Sonmez, Pınar Mutlu, Cinla Ozlevent et al. · 0 citations

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