Open access
Jul 2026
Targeting genome organizer Satb1 in regulatory T cells safely and potently enhances cancer immunity 2309560
Deletion of Satb1 specifically in Tregs impaired the function of Satb1+ pro-tumorigenic Tregs, leading to enhanced CD8+ T cell antitumor immune responses, and complete tumor eradication without any systemic autoimmune conditions.
Ephraim A. Ansa-Addo, Parviz Azimnasab-sorkhabi, Musab Bouhajra et al.
· Journal of Immunology · 0 citations