Author

N. Ahmed

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Sep 2026

Design, synthesis, molecular docking, ADMET and anticancer evaluation of novel pyridine/thiazole hybrids as dual VEGFR-2 and EGFR kinase inhibitors.

The synthesis of a number of novel pyridine/thiazole hybrids 1 to 6a,b and their screening as possible anticancer drugs through dual targeting of VEGFR-2 and EGFR are highlighted and every synthesized compound demonstrated minimal toxicity toward VERO normal cells.

N. Ahmed, Rizk E. Khidre, Mohamed R. Khidre et al. · Bioorganic chemistry (Print) · 0 citations

Review Jul 2026

Fourth-generation allosteric EGFR inhibitors: Structure-based scaffold analysis and SAR exploration.

It is established that allosteric EGFR inhibition represents a clinically viable strategy for addressing osimertinib resistance, with lead candidates ready for clinical translation.

Ibrahim Mohammed Hepishy, Mo'men Salem, A. El-Morsy et al. · Bioorganic chemistry (Print) · 0 citations