Author

N. Akgun-Unal

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Open access Oct 2026

The effect of resveratrol on the hippocampus in the pentylenetetrazol (PTZ) - dependent kindling model of epilepsy

Epilepsy is a long-term neurological condition marked by neuronal excitotoxicity, oxidative stress, and inflammation of the nervous system. This study seeks to explore the neuroprotective and anti-seizure properties of Resveratrol (RSV) and the molecular processes involved in a pentylenetetrazol (PTZ)-induced kindling...

O. Unal, N. Akgun-Unal, E. S. Tiryaki et al. · BMC Complementary Medicine a... · 0 citations

Open access Sep 2026

Resveratrol’s Neuroprotective Effects on the Retina in a Pentylenetetrazol-Induced Epilepsy Model in Rats: Insights into SIRT1 Signaling, Apoptosis, and Gliosis

Preclinical findings suggest that Resveratrol represents a promising protective strategy against epilepsy-associated retinal damage, though further clinical validation is warranted to establish its therapeutic safety and efficacy in human patients.

O. Unal, N. Akgun-Unal, Elif Gulbahce-Mutlu et al. · Antioxidants · 0 citations

Open access Aug 2026

Neuroprotective Effects of Zinc Sulfate Against Type 2 Diabetes-Induced Encephalopathy in Aged Rats

ZnSO4 supplementation provides potent, multifaceted neuroprotection against T2DM-associated neurodegeneration by regulating systemic dyslipidemia, restoring redox homeostasis, activating the SIRT-1/BDNF anti-apoptotic pathway, and preserving structural integrity.

O. Unal, N. Akgun-Unal, E. S. Tiryaki et al. · International Journal of Mol... · 0 citations

Open access Aug 2026

The protective role of zinc in hyperglycemia-induced kidney injury: molecular modulation of ferroptosis, apoptosis, and fibrosis

Aims: This study aimed to examine the molecular, immunohistochemical, and histopathological impacts of zinc (ZnSO₄) supplementation on apoptosis, ferroptosis, and fibrosis pathways in the kidney tissue of aged female rats with type 2 diabetes, induced by a high-fat diet and streptozotocin (STZ). Methods: Female rats ag...

N. Akgun-Unal, G. Altun, Serpil Çilingiroğlu Anlı · Journal of Medicine and Pall... · 0 citations