Open access
Jul 2026
Visualization of stepwise derepression of TFIIH in global genome nucleotide excision repair
High-resolution structures of three NER intermediates are determined that visualize how TFIIH arrives at sites of DNA damage in an autoinhibited state and how autoinhibition is released via previously undescribed intermediates, contributing to a mechanistic understanding of human DNA repair.
Natàlia de Martín Garrido, Callum A. F. Haste, Junjie Feng et al.
· Science Advances · 0 citations