Author

N. Beutler

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Open access Sep 2026

De novo minibinders targeting RH5 achieve nanomolar inhibition of blood-stage malaria replication

Malaria kills ∼600,000 people annually despite recently deployed vaccines. The parasite’s blood-stage invasion of erythrocytes, driven by the essential, non-redundant interaction between Plasmodium falciparum RH5 and erythrocyte basigin, remains a leading therapeutic target. Here, we designed de novo mini-proteins (“mi...

Jason Hsiao, Melina Shamshoum, Abhiram Chalamalasetty et al. · bioRxiv · 0 citations

Open access Aug 2026

Directed evolution of a stem-helix–targeting antibody enables MERS-CoV cross-neutralization through enhanced binding affinity

The isolation of a human monoclonal antibody from a SARS-CoV-2 convalescent donor that targets the conserved S2 stem helix region is reported, demonstrating the potential of in vitro affinity maturation to expand the neutralization breadth of stem-helix-targeting antibodies across divergent betacoronaviruses.

Panpan Zhou, M. Yuan, Yue-Xiu Zhang et al. · PLoS Pathogens · 0 citations