Adolescence is a critical period of brain development during which the endocannabinoid system continues to mature. These developmental changes may contribute to age-related differences in the association between cannabis use and large-scale functional network organisation, yet this association remains incompletely char...
Elizabeth J. Davies, N. Ertl, Tom P. Freeman et al.· bioRxiv· 0 citations
Neuroplasticity, the brain’s capacity to reorganise its structure and function, is a transdiagnostic feature across psychiatric and neurodegenerative diseases and a putative mechanism of action for pharmacological interventions. [¹¹C]-UCBJ positron emission tomography (PET), which quantifies synaptic vesicle glycoprote...
C. Agnorelli, J. Peill, D. Kurtin et al.· bioRxiv· 0 citations
Findings are broadly consistent with corticostriatal models of GD and identify candidate circuit-level differences for independent replication, but larger, more diverse and longitudinal samples are required to establish their reproducibility, temporal direction and clinical relevance.
Rayyan Zafar, N. Ertl, Luke Donegan et al.· bioRxiv· 0 citations
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