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N. Franceschini

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Open access Sep 2026

Phenome- and laboratory-wide meta-analyses of sickle cell trait reveal multi-system disease associations

Sickle cell trait (SCT) is increasingly recognized as a risk factor for adverse health outcomes. We utilized three large US electronic health record-based biobanks (Vanderbilt University Medical Center’s BioVU, Penn Medicine Biobank, and All of Us) to conduct phenome-wide association (PheWAS) and clinical laboratory-wi...

M. Hysong, Megan M. Shuey, T. Miller-Fleming et al. · 0 citations
Open access Sep 2026

Explaining the unexplained admixture mapping signals via rare variants: the HCHS/SOL

This work integrates rare-variant analysis within the AM framework, highlights the potential interplay between variant types and establishes a novel strategy to guide future fine-mapping and causal variant identification in admixed populations.

Xue-Ying Chen, Maria Argos, Bing Yu et al. · 0 citations

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