The decay of the Lef1 - Srsf3 -miRNA axis as a core molecular alteration underlying SC aging is defined and revealed that local SC aging may contribute to organismal aging.
Y. Ikuno, Koichiro Watanabe, Y. Kande et al.· Cell Death & Disease· 0 citations
This focused narrative review reappraises biologic therapies in SSc using a manifestation-based framework spanning cutaneous, pulmonary, vascular, gastrointestinal, musculoskeletal, and global or composite outcomes and argues that vasculopathy may represent an upstream pathogenic layer that constrains the disease-modif...
Souta Kobayashi, Y. Ikuno, Masahiro Yamada et al.· Sclerosis· 0 citations
It is shown that dietary RJ enhances stem/progenitor cell activity with age- and tissue-dependent Chi3l1 -mediated increases in CD206-positive macrophages, suggesting that Chi3l1 is a physiologically regulated immune mediator, rather than a pathogenic factor in disease contexts, highlighting the importance of mechanis...
Y. Kande, Y. Ikuno, Ayano Narumoto et al.· npj Aging· 0 citations
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