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Author

N. Fujimoto

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Review Open access Sep 2026

Biologics in Systemic Sclerosis: An Organ- and Manifestation-Specific Reappraisal of What Has Changed, What Has Not, and Why

This focused narrative review reappraises biologic therapies in SSc using a manifestation-based framework spanning cutaneous, pulmonary, vascular, gastrointestinal, musculoskeletal, and global or composite outcomes and argues that vasculopathy may represent an upstream pathogenic layer that constrains the disease-modif...

Souta Kobayashi, Y. Ikuno, Masahiro Yamada et al. · 0 citations
Open access Jul 2026

Royal jelly ameliorates age-associated stem cell dysfunction with Chi3l1-mediated increase in CD206-positive macrophages

It is shown that dietary RJ enhances stem/progenitor cell activity with age- and tissue-dependent Chi3l1 -mediated increases in CD206-positive macrophages, suggesting that Chi3l1 is a physiologically regulated immune mediator, rather than a pathogenic factor in disease contexts, highlighting the importance of mechanis...

Y. Kande, Y. Ikuno, Ayano Narumoto et al. · 0 citations

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