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Author

N. Fujiyama

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Open access Aug 2026

Everolimus-Involving Immunosuppression Attenuates Renal Interstitial Fibrosis Through Modulation of Mammalian Target of Rapamycin-Related Signal Transduction

Chronic allograft dysfunction, driven by interstitial fibrosis and tubular atrophy, remains a major cause of long-term renal allograft loss. Everolimus (EVR), a mammalian target of rapamycin (mTOR) inhibitor, may reduce fibrosis through antifibrotic effects and calcineurin inhibitor minimization. This study aimed to ev...

Takuro Saito, M. Saito, Ryohei Yamamoto et al. · 0 citations
Open access Oct 2026

Identifying Mild Cognitive Impairment from Routinely Collected Physical, Functional and Psychosocial Measures in Community-Dwelling Older Adults: A Comparative Machine-Learning and Regression Modelling Study in the Northern Japanese ORANGE Registry

Background: Community health check-ups routinely collect non-cognitive data. Whether these support mild cognitive impairment (MCI) triage, and whether machine learning outperforms regression, is unclear. Methods: Cross-sectional analysis of 2650 community-dwelling adults aged ≥65 in Akita, Japan (2018–2025). MCI was de...

Ayuto Kodama, Takako Ohnuma, Kana Sasaki et al. · 0 citations

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