N. Galić

Comprehensive analysis of peptide pharmaceutical: Development of three orthogonal chromatographic methods and characterization of bivalirudin degradation products by high-resolution mass spectrometry.

Bivalirudin is a synthetic oligopeptide used as an anticoagulant for the treatment of acute coronary syndromes and for the prevention of thrombosis in patients undergoing percutaneous coronary intervention. As peptides are complex molecules that may exhibit inherently complex impurity profiles, three orthogonal ultra-p...