N. Goldhammer

Same-cell mapping of epigenetic regulatory state to functional proteomic output

To profile chromatin accessibility and cytoplasmic protein from the same cell, we introduce Proteo-Seq, a single-cell tool that physically routes each cell’s cytoplasmic proteome to either targeted or discovery proteomics and each cell’s intact nucleus to single-nucleus ATAC sequencing (snATAC-seq). The device comprise...