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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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N. Gomez-Sequeda

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Open access Sep 2026

LRRK2 Kinase Inhibitor PF-06447475 Protects Against Alzheimer’s Disease-Associated Pathology in PSEN1 I416T Cholinergic-like Neurons

Familial Alzheimer’s disease (FAD) is an accelerated form of dementia affecting cholinergic neurons. Despite several efforts, no single drug or treatment has demonstrated complete efficacy. Therefore, finding effective therapeutic agents is imperative. Previous studies have shown that the PSEN1 I416T variant induces FA...

N. Gomez-Sequeda, M. Jimenez-Del-Rio, C. Velez-Pardo · 0 citations

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