Author

N. Gremke

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Open access Sep 2026

A pro-inflammatory metastasis-associated macrophage subset induces tumor-promoting mesothelial cell conversion in ovarian cancer via IL-1α secretion

Tumor-associated macrophages (TAMs) are key regulators of the tumor microenvironment, yet the functional specialization of TAM subsets in metastatic progression remains incompletely defined. Here, we characterized distinct TAM populations contributing to tumor-promoting mesothelial cell conversion in high-grade ovarian...

Sophie Heidemann, F. Finkernagel, A. Steitz et al. · Cell Death and Disease · 0 citations

Open access Jul 2026

AI-enabled clinical decision support in breast cancer care: a blinded multicenter benchmarking study comparing medically specialized with a general-purpose system

The results indicate that while regulatory clearance and domain specialization address key requirements for AI-enabled clinical decision support systems, these factors alone do not translate into superior performance in breast cancer care.

Jonas Freudenberg, J. Knitza, N. Gremke et al. · Journal of medical systems · 0 citations