N. Hacohen

Personalized neoantigen-targeting cancer vaccines in ovarian cancer: a phase 1 trial.

Abstract B096: Immune and stromal features of durable complete response to radiation and dual immune checkpoint blockade in pancreatic cancer

It is suggested that productive immunotherapy responses in PDAC require not only tumor-reactive T cells, but also a stromal-vascular niche capable of supporting their recruitment, recirculation and persistence.

RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation

The RNF43 p.G659fs (RNF43659mut) mutation occurs in 8% of colorectal cancers (CRCs) and is enriched in microsatellite instability–high (MSI-H) tumors. Although RNF43659mut promotes tumor growth through phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin (PI3K/AKT/mTOR) activation independent...

CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer.

These findings highlight Dusp5 and Zfp219 as critical drivers of age-related T cell dysfunction that can be targeted to rejuvenate antitumor immunity in older cancer patients.

A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity 2258066

It is shown that myeloid-derived suppressor cells (MDSCs) act as a key immunologic pivot point in severe COVID-19, and this multimodal and high-dimensional dataset with curated clinical metadata provides a foundational and clinically relevant resource for modeling host immune response biology in health and disease.

Scaling measurements of peptide-HLA complex stability using user-defined libraries and mass spectrometry 2310029

A high-throughput assay to quantify stability of thousands of user-defined pHLA produced in E. coli and generated customizable pHLA stability datasets which show how peptide sequence motifs affect pHLA stability, and may be helpful for improving the authors' mechanistic understanding of pHLA stability.

Scalable single-cell isoform profiling with sequencing-by-expansion

This work establishes SBX and the AXELIOS 1 as a transformative platform for high-scale single-cell isoform sequencing and demonstrates that this consensus approach successfully captures the vast isoform diversity of single-cell libraries and enables the accurate measure of differential isoform expression across distin...