Author

N. Hong

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Open access Sep 2026

Discovering repurposable drugs for Alzheimer’s disease and related dementias: target trial emulation using decentralised real-world data

Summary Background Alzheimer’s disease and related dementias (ADRD) affect nearly 6.9 million Americans, with the number expected to triple by 2050, while disease-modifying therapies remain unavailable. Drug repurposing, which identifies new indications for already approved medications, offers a more efficient and cost...

Qiong Wu, Lu Li, Yu-Qing Lei et al. · EBioMedicine · 0 citations

Preprint Jul 2026

A safety-oriented hypothetico-deductive framework for AI-assisted differential diagnosis

The findings suggest that engineering diagnostic AI as a safety-oriented reasoning framework, rather than optimizing raw predictive accuracy alone, can provide a safer, more transparent, and clinically meaningful layer of bedside decision support for acute care workflows.

F. Ma, Mauro Giuffrè, D. Wright et al. · 0 citations