Open access
Sep 2026
Nx3 Is a Z-Disk Structural and Signaling Hub That Is Reduced in Heart Failure.
BACKGROUND Nx3 (novex-3) is an exceptionally small isoform of the giant protein titin, whose structural and functional roles within the sarcomere remain poorly understood. METHODS AND RESULTS We used a comprehensive, multimodal approach to define the key properties of Nx3 in healthy and failing hearts, including its...
W. Linke, Lisa Kümper, A. Fomin et al.
· Circulation Research · 0 citations