ANALGESIC AND ANTI-INFLAMMATORY INVESTIGATION OF THIOPHENE MANNICH BASES IN RATS
Evaluation of analgesic and anti-inflammatory activity demonstrated that test compound 1, significantly prolonged response latency in the hot plate method, reduced the number of abdominal writhes induced by 1% acetic acid, decreased carrageenan- and formalin- and formalin-induced paw edema, and reduced the volume of ex...