LRRC8/VRAC channels at the biophysical interface between cell-volume regulation and context-dependent cell-state transitions.
Cell volume is a dynamic physical state variable that changes membrane geometry, intracellular ionic strength, macromolecular concentration, molecular surface density, and reaction kinetics. Leucine-rich repeat-containing 8/volume-regulated anion channels (LRRC8/VRACs) provide a molecularly tractable system for testing...