Open access
Oct 2026
The host transcriptional response to real-world cryptococcosis in the setting of advanced HIV disease defines dysregulated immune responses that underlie increased vulnerability to infection
Background Cryptococcus causes life-threatening infections; however, immune programs driving pathogenesis of these infections in the human host remain incompletely described. We leveraged whole-blood transcriptomic analysis to define distinct, conserved elements of the host immune response in participants with cryptoco...
B. Sim, J. Steinbrink, Cameron Miller et al.
· Journal of Infectious Diseas... · 0 citations