Author

N. Kocaturk

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Open access Oct 2026

Development of a NanoBRET assay platform to detect intracellular target engagement in living cells for the Glycine Transporter 1 (SLC6A9)

Glycine transporter 1 (GlyT1) is a clinically investigated target whose conformational plasticity enables ligands to engage distinct extracellular and intracellular binding sites. However, methods to directly quantify intracellular binding remain limited and largely rely on radioligand-based approaches. Here, we report...

M. H. Jensen, Ioannis P. Avgeris, N. Kocaturk et al. · bioRxiv · 0 citations

Open access Aug 2026

Targeted degradation of alpha-synuclein impedes PFF-induced aggregation

The Affinity-directed PROtein Missile system is employed and targeted degradation of α-synuclein impedes the pre-formed fibril (PFF)-induced aggregation of α-synuclein in primary neurons derived from rats expressing human α-synuclein.

Bill Carton, Géraldine Gelders, Gajanan Sathe et al. · npj Parkinson's Disease · 0 citations