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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

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N. Lambert

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Open access Sep 2026

G protein diffusion states reveal receptor binding dynamics at single-molecule scale.

G protein-coupled receptors (GPCRs) signal through heterotrimeric G proteins, yet the kinetics of receptor-G protein interactions in cells remain poorly understood. Using single-molecule imaging, we tracked individual Gαi1 proteins diffusing in the plasma membrane, expecting that receptor binding should slow these rapi...

Signe Mathiasen, Jozsef Meszaros, Chase M. Webb et al. · 0 citations
Open access Sep 2026

Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

Phospholipase C β (PLCβ) enzymes are activated by heterotrimeric G protein subunits, increasing hydrolysis of phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) at the plasma membrane. All four human PLCβ isoforms (PLCβ1–4) are activated by Gαq, whereas PLCβ1–3 are activated to varying extents by Gβγ. The binding sites...

Isaac J. Fisher, Kanishka Senarath, Kennedy Outlaw et al. · 0 citations

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