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A prominent family of low-rank LLM optimizers, pioneered by GaLore, performs gradient-subspace projection: at each step, they project the gradient into a low-dimensional subspace and map the update back to the full model. Most existing work either recomputes the gradient subspace at certain intervals, or performs post-...
Malignant gliomas are the most common primary brain tumors, with dismal outcomes. Pet dogs have been proposed as a valuable model for studying gliomas. Here, we compare spontaneously occurring gliomas from adult and pediatric human and canine patients, focusing on the tumor microenvironment (TME) and the canonical path...
These findings demonstrate that the Nav1.2-L1342P mutation drives a multifaceted disease phenotype, including network hyperexcitability and disruption of pathways related to neuronal and synaptic functions, which advances understanding of SCN2A-related developmental and epileptic encephalopathy (DEE).
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