Open access
Sep 2026
Precise pH-triggered cleavage of PEG-lipid conjugates drives endosomal escape of siRNA from fusogenic lipid-based nanoparticles.
Novel pH-triggered RNA-LNPs (ZK2 LNPs) that comprise PEG-lipid oxime conjugates (5 mol%), prepared in situ using pH-reversible aminoxy-aldehyde click chemistry represent a powerful next generation LNP technology and demonstrate excellent LNP tolerability in vivo.
Zdeněk Kratochvíl, Dattary Shivajirao Bhosale, Melanie Schürz et al.
· International journal of pha... · 0 citations