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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

N. Mosammaparast

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2 papers indexed here

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Open access Sep 2026

Substrate Profiling of RNF216 Uncovers a Translation-Linked OTUD4 Regulatory Axis

Mutations in the E3 Ubiquitin (Ub) ligase RNF216 cause Gordon Holmes syndrome (GHS), a neurodegenerative disorder accompanied by neuroendocrine disruption. We developed an orthogonal ubiquitin transfer (OUT) platform to capture RNF216 substrates in neuronal cells and identified OTUD4, a deubiquitinating enzyme (DUB) mu...

Wei Wei, Ruochuan Liu, Jing Zhang et al. · 0 citations
Open access Sep 2026

Human MutLα activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity.

Alkylation chemotherapy is commonly used against tumors such as glioblastoma, yet resistance often develops through downregulation of mismatch repair (MMR). Previous work has established that loss of MMR prevents the excision of the thymine-containing strand across O 6meG-T mismatches, thereby avoiding the futile repai...

Mohamed E. Ashour, Ellissa Krekeler, Monika Chandan Bhowmik et al. · 0 citations

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