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Author

N. Murata-Kamiya

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Review Open access Sep 2026

Differential tyrosine phosphorylation status of the nuclear scaffold Parafibromin/CDC73 determines its role in cancer development.

Parafibromin/CDC73 is a multifunctional nuclear scaffold protein with context-dependent roles in tumorigenesis, functioning as both a tumor suppressor and an oncogenic driver. Originally identified as the product of the HRPT2 tumor suppressor gene, which is mutated in hyperparathyroidism-jaw tumor syndrome, Parafibromi...

Atsushi Takahashi-Kanemitsu, Ippei Kikuchi, N. Murata-Kamiya et al. · 0 citations

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